The cast of early modern Spanish writers.

Teresa de Cartagena (Burgos, c.1425– after 1478) was a groundbreaking Spanish writer, mystic, and nun who emerged as the first female Spanish-language writer and mystic in late medieval Castile. Born into a prominent converso family (Christians of Jewish lineage) in Burgos, she likely received an exceptional education for a woman of her time, possibly studying at the University of Salamanca as she mentions in her writing. Teresa initially entered the Franciscan Monastery of Santa Clara in Burgos around 1440, but later transferred to the Cistercian Abbey of Santa María la Real de Las Huelgas in 1449, possibly due to growing hostility toward conversos. It was during this period that Teresa became deaf, an affliction that profoundly shaped her spiritual and intellectual life, leading her to compose two significant works: "Arboleda de los enfermos" (Grove of the Infirm), which explored her spiritual journey through illness and solitude, and "Admiraçión operum Dey" (Wonder at the Works of God), written shortly after as a defense against male critics who doubted a woman could have authored such an eloquent text, boldly arguing for women's intellectual equality and claiming that if God could bestow gifts of intellect on men, He could equally bestow them on women.

Saint Teresa of Ávila (1515–1582) was a Spanish mystic, Carmelite nun, and religious reformer. Born in Ávila, Spain, to a converso family (her grandfather was a Jewish convert to Christianity), Teresa entered the Carmelite Order at age 20 despite her father's disapproval. Her literary accomplishments are remarkable given the restrictions on women's education and intellectual activity in 16th-century Spain. Teresa's writings, composed during a period of intense religious reform and amid frequent illness and opposition, established her as one of the most important prose authors in Spanish literary history. After experiencing a profound spiritual conversion through illness and mystical experiences—including visions, ecstasies, and what she described as a transverberation of her heart—Teresa began writing as a means of explaining and defending her interior spiritual life. Her autobiography, "The Life of Teresa of Jesus," is considered a masterpiece of spiritual literature and Spanish prose. Her major works also include "The Way of Perfection" (1566), written to instruct her nuns in prayer, and "The Interior Castle" (1577), a sophisticated spiritual guide. Canonized in 1622, Teresa was proclaimed the first female Doctor of the Church by Pope Paul VI in 1970, recognizing her extraordinary contributions to Christian spirituality and mystical theology through her writings.

María de Jesús de Ágreda (1602-1665) was a Spanish Conceptionist abbess, mystic, and prolific spiritual writer who gained renown in the 17th century. Born in Ágreda, Spain, she became abbess of the Monastery of the Immaculate Conception at just 25 years of age and maintained this leadership role until her death. She authored 14 books, most notably the extensive "Mystical City of God," an eight-book series detailing revelations about the Virgin Mary's life that she claimed to have received directly from the Blessed Virgin herself. Among her lesser-known but significant works is the "Tratado de la redondez de la tierra" (Treatise on the Roundness of the Earth), a cosmological and geographical essay born from what was called "infused science" or divine knowledge, in which she described the world as seen from space. Her writings, which follow the Franciscan theologian Duns Scotus, are characterized by their ascetic and mystical nature, with a strong defense of the Immaculate Conception. Beyond her literary contributions, Sor María maintained a remarkable correspondence with King Philip IV of Spain spanning over twenty years and more than 600 letters, in which she served as both spiritual and political advisor to the monarch.

Ursula de Jesús (1604–1668) was a Black mystic who lived in 17th century Lima, Peru, where she spent forty-three years as a slave, including twenty-eight years in the Franciscan Convent of Santa Clara. After being freed, she became a donada—a servant who took religious vows but wasn't granted full status as a nun. Beginning in 1650, her confessors ordered her to record her numerous visions, particularly of souls in purgatory, creating a diary that reveals both her spiritual experiences and everyday concerns. Though she practiced extreme physical penances typical of Spanish mystics, including wearing a hair shirt and crown of thorns while performing manual labor, her plainspoken diary articulates a theology that subtly challenged colonial Lima's racial hierarchies, particularly when she questioned whether Black women could go to heaven. Her writings navigate the complex relationship between Christian humility and self-worth in the context of slavery and racism, as she struggled to reconcile her belief in her own lowliness with her visions affirming the equal value of all souls in God's eyes.

Catarina de San Juan (c. 1607-1688) was born as Mirra in Mughal India. After being baptized in Kochi, she was taken to Manila in the Philippines, where she was purchased by a Spanish merchant named Miguel de Sosa who brought her to Mexico in 1621 as part of the transpacific slave trade. After being freed upon her master's death, Catarina devoted herself to an ascetic religious life in Puebla, where she gained renown for her spiritual visions, prophecies, and mystical experiences, including regular conversations with Jesus Christ (whom she considered her celestial husband) and the Virgin Mary. Though illiterate, her religious experiences were extensively documented by her Jesuit confessor Alonso Ramos, who produced a three-volume hagiography that became the largest book published in colonial Mexico at the time. Her mystical writings—as recorded by Ramos and other priests—described profound spiritual journeys, including astral projections to Asia, prophecies about notable deaths, and visions of her parents traveling from India to Mexico on their knees. These works initially made her a venerated spiritual icon in Puebla, with followers converting her humble cell into an altar, until the Spanish Inquisition intervened in 1691, censoring her writings and prohibiting her cult on charges of blasphemy for attributing divine powers to her.

Sor Juana Inés de la Cruz (1651-1695), also known as "The Tenth Muse," was a renowned Jeronymite nun and Mexican literary figure considered one of the most important writers of the Spanish Golden Age. Born in San Miguel Nepantla, New Spain (now Mexico), she displayed remarkable intellectual abilities from an early age, teaching herself to read and write by age three. Despite restrictions on women's education, she mastered Latin in just twenty lessons and accumulated extensive knowledge in theology, philosophy, mathematics, and natural sciences. Sor Juana produced an impressive body of work spanning various genres: lyric poetry, religious and secular plays, philosophical essays, and theological critiques. She boldly defended women's intellectual rights in her famous "Respuesta a Sor Filotea" (Response to Sister Philotea), challenging the patriarchal restrictions of her time. Her mastery of the Baroque style, incorporating complex wordplay, sophisticated metaphors, and multilingual elements including Nahuatl, established her as a literary pioneer whose influence extends well beyond her brief 47 years of life.